Whole-body PBMT

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Whole-body PBMT

Photobiomodulation Therapy (PBMT)

PBM refers to a process where particular wavelengths of light penetrates through the cells to generate ATP in the mitochondria.

Such term has been introduced as a key word for future medical treatment on the National Health Institute’s Medical Subject Heading (MeSH) from 2016. It has been known as Low Level Laser Therapy (LLLT) , but the standard term of such treatment, technology is justified as Photobiomodulation (PBM).

PBM therapy acknowledged via clinical studies

There are more than 5,000 research studies on LLLT, now known as Photobiomodulation, out of these, many significant studies have been listed on the National Library of Medicine (NCBI) website.

PBMT Human Clinical Trials

PBM has been researched for more than a decade on various different diseases and had been acknowledged for its effectiveness. The list below shows some of the studies outlined. This would be a great reference point for a new clinical trial as well.

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PBM Human Clinical Trial

Click on the categories to see the related studies

Below chart displays several cases on randomized clinical trials (total patients, 6,500)

Photobiomodulation : systematic reviews
Category Author Review Published Year N n Rating Results
periodontitis University of Hong Kong Ren M 2017 7 180 C /1 Photobiomodulation therapy (PBMT) had helped to reduce the pocket depth within 1-2 months.
Diabetic foot ulcer Tchanque ... S 2016 4 131 C PBMT accelerated the healing process
Hair loss Zarei S 2016 5 394 B / C PBMT was beneficial for recovering hair loss (androgen) in both genders
Healing tooth extract Ribeiro S 2016 11 555 C PBMT had reduced the pain
Delayed onset muscle syndrome (DOMS) Nampo M 2016 15 317 C PBMT had been criticized for not being effective. (Baroni & Leal-Junior, 2016). ( Baroni & Leal-Junior 2016 ).
Chronic backache Chronic backache M 2015 7 211 B / C / PBMT did not reduce or increase the pain
Beard disorder Chen M 2015 14 454 C / PBMT had not reduced the pain but had provided functional improvement
Athletic ability Leal-Junior M 2015 13 134 C PBMT increased the sports ability and accelerated the recovery after the exercise
Arthritis (knees) Huang M 2015 9 518 B PBMT did not reduce the pain. However, there had been a positive outcome shown at a different study (Stausholm et. al, 2016)( Stausholm et al., 2016 ).
Orthodontic treatment Ge M 2015 9 211 C PBMT notably helped with the teeth movement
Lymphedema (breast cancer) Smoot M 2014 7 262 C PBMT reduced the pain and upper limb volume
Neck pain SBU S 2014 18 1007 C PBMT reduced the pain
Mucositis inflammation Oberoi M 2014 18 1144 B PBMT reduced the pain and lessened the risk of worsening inflammation
Sports performance Borsa S 2013 10 147 B PBMT increased the sports performance and accelerated the recovery after the exercise
Chronic neck pain Gross M 2013 2 109 C PBMT improved the following markers (pain, disability, QoL, and GPE).
Tooth extraction Brignard. S/td> 2012 9 599 C PBMT did not do any change
Tendinopathies Tumilty M 2010 25 963 B / Out of all the studies, 12 studies indicated that PBMT was effective while 13 studies suggested that PBMT showed no change
Neck pain Chow M 2009 16 820 B PBMT reduced the pain
Tennis elbow Bjordal M 2008 13 730 B / C PBMT reduced the pain
Acute pain Bjordal S 2006 9 609 B / C PBMT reduced the pain
Neck pain Chow S 2005 5 273 C PBMT reduced the pain
Chronic joint disorder Bjordal S 2003 11 565 C PBMT reduced the pain
M = 메타 분석; S = 체계적인 검토; N = 인원 수; n = 과목 수
Above clinical result chart includes the analysis on the quality of such results. B indicates normal effectiveness,
C indicates weak effectiveness. Such analysis had been evidenced based on the standards used by UK Cochrane Library ( https://www.cochrane.org/ ) .
From 2014 to 2018, a lot of these systematically reviewed trials have been published.
Currently, PBM research is ever increasing at a rapid speed and there are over 400 related studies published worldwide. We project that by 2020,
there would be more than thousand related published studies available.
To conclude, PBMT is beneficial for various different diseases.
Click to view more related studies

PBMT at cellular, mitochondrial level

  • Increase in oxygen
    consumption
  • Increase in the mitochondrial membrane
  • Increase in ATP
    and cAMP
  • Release of Nitric Oxide (NO)
  • Short occurrence of ROS
  • Molecular change to the calcium

Signaling through stimulating the mitochondria

  • Generation of the growth factor
  • extracellular matrix deposition
  • Increase in the cellular multiplication and activity
  • Anti-apoptosis suppression

COVID-19 prevention and treatment with PBM therapy

Clinical studies are being continuously released on PBM therapy in the effect of treating and/or preventing COVID-19 that has driven the world to pandemic. Click on the button to view the studies from the National Institute of Health: Library of Medicine and others.
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Disclaimer: This content consists of medical papers and academic information and is not intended to diagnose, treat diseases, or replace a doctor's advice, and all outcomes may vary from person to person.
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